• 黄金城集团

    NIBS using tDCS to mitigate aggression

    Paola Di Maio

    Published: 2024-06-06 DOI: 10.17504/protocols.io.261ge5597g47/v1
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    Disclaimer

    The protocol is published to facilitate sharing and reuse of non invasive neuromodulation research outcomes. The protocol describes a procedure which has been tested, peer reviewed and published by reputable sources with supporting data.

    The source of the protocol together with critical information about its safe application are provided without warranties.

    The author is not responsible for unexpected, undesired or adverse outcomes of the application of the protocol.

    Readers, researchers, clinicians and healthpractictioners accessing this material are responsible for verifying the content and relevance of the protocol and its application, and use it at their own discretion, taking into account the the safety warnings.

    Abstract

    Protocol Description: Non Invasive Neuromodulation procedure using tDCS (transcranial direct current stimulation) to mitigate aggressive behavior in healthy adults

    Condition: tendency to exhibit overly aggressive behavior

    Safety: The procedure must be administered by trained personnel, and the subject must obtained medical clearance

    Contraindications: Do not administer this procedure if the subject has metallic implants near the

    electrode sites; is epileptic; has unstable medical conditions; neurological, cardiovascu-

    lar, or psychiatric illness; participates in another noninvasive brain

    stimulation study on the same day; has history of adverse reactions to tDCS;

    Do not apply electrodes to skin with lesions

    tDCS intervention. using a battery-driven, constant-current stimulator .

    DLPFC pre frontal cortex

    Tdcs transcranial direct current stimulation

    Before start

    Two hours before or after main meals

    wearing no metal objects

    comfortable clothing

    sitting in semi reclined position

    Steps

    Protocol Description

    1.

    Two anodal electrodes are placed over the DLPFC bilaterally (F3 and F4) according to the International 10 –20 EEG system.

    2.

    A constant current of 2 mA (1 mA to each DLPFC site) is applied for 20 min through saline-soaked sponge electrodes (5 5 cm).

    3.

    A single extracephalic cathodal electrode (5 7 cm) is placed at the posterior base of the neck to minimize unintentional effects of inhibitory stimulation on brain Activity.

    4.

    Following standard tDCS protocol, stimulation commences after 30 s ramp-up period. The current is ramped down over the last 2 s.

    5.

    Check the subject throughout the procedure and discontinue if the subject shows discomfort

    Safety Warnings

    6.

    Use tDCS equipment and accessories compliant with international standards, by trained personnel

    7.

    In pre clinical studies, the procedure can mitigate Aggressive behaviour

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