Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

Jiaxuan Chen, Aleksandra Ellert-Miklaszewska, Stefano Garofalo, Arindam K. Dey, Jingjie Tang, Yifan Jiang, Flora Clément, Patrice N. Marche, Xiaoxuan Liu, Bozena Kaminska, Angela Santoni, Cristina Limatola, John J. Rossi, Jiehua Zhou, Ling Peng

Published: 2020-12-03 DOI: 10.1038/s41596-020-00418-9

amphiphilic dendrimer

siRNA delivery

primary immune cells

functional siRNA delivery

immune system manipulation

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Using siRNAs to genetically manipulate immune cells is important to both basic immunological studies and therapeutic applications. However, siRNA delivery is challenging because primary immune cells are often sensitive to the delivery materials and genera
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ACKNOWLEDGMENTS

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Synthesis and use of an amphiphilic dendrimer for siRNA delivery into primary immune cells

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