Translation of11C-labeled tracer synthesis to a CGMP environment as exemplified by [11C]ER176 for PET imaging of human TSPO

Yi Zhang, Jinsoo Hong, Sanjay Telu, William H. Miller, H. Umesha Shetty, Cheryl L. Morse, Victor W. Pike

Published: 2021-08-05 DOI: 10.1038/s41596-021-00584-4

PET imaging

TSPO

11C-labeled radiotracer

CGMP environment

[11C]ER176

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Radiotracers labeled with carbon-11 (t1/2 = 20.4min) are widely used with positron emission tomography for biomedical research. Radiotracers must be produced for positron emission tomography studies in humans according to prescribed time schedules while
Introduction
Materials
Procedure 1: presynthesis equipment setup
Procedure 2: preparation of QC equipment
Procedure 3: radiosynthesis of [11C]ER176
- Delivery of [11C]carbon dioxide and preparation of [11C]iodomethane
- Radiosynthesis, purification and formulation of [11C]ER176
Procedure 4: QC of [11C]ER176
Troubleshooting
Timing
Anticipated results
- References
- References
References
ACKNOWLEDGMENTS
ACKNOWLEDGMENTS

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Translation of11C-labeled tracer synthesis to a CGMP environment as exemplified by [11C]ER176 for PET imaging of human TSPO

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